ON THE COUCH
Check this: you probably think 'Man, that IOYC's Mind is so Fact-laden, how can he take it?' I decided to ask myself the very same question in the form of telling it to a Licenced Hypno Tribal Counsellor. Shit didn't go according to plan, but I like to live 'on the Edge'.
'LOL your Mind has AIDS'
IOYC: So, Counsellor [NAME CENSORED]. How would you compare my Mind to most. Is it in a Problem?
Counsellor [NAME CENSORED]: I tell you what - fuck no. That shit is so dope it hurts my Qualifications.
IOYC: Can you please be fucking serious?
Counsellor [NAME CENSORED]: Let me touch it.
IOYC: Maybe I should Counsel you with this Fist.
Counsellor [NAME CENSORED]: Okay, okay. Let's talk about Mums.
IOYC: Let's talk about me exploding your Childs.
Counsellor [NAME CENSORED]: *cries*
IOYC: LOL you are such a Shit Counsellor.
Counsellor [NAME CENSORED]: I am so rethinking my life choices right now.
IOYC: Dope Transference - I can feel what it is like to suck.
Anyway I totally fucked that shit off and started thinking about other things, like this:
When Shin-ichiro Imai, a postdoc in Guarente's lab, mixed Sir2p, NAD, and part of a histone (a small protein commonly found in association with DNA in chromatin) in a test tube to see if Sir2p added ADP-ribose to the protein tails, he was shaken by the results. The histone molecules did not get heavier, as they would if weighed down by an extra ADP-ribose group. Instead, many of them got lighter by exactly 42 atomic masses. Guarente was reported to shout, "That might be deacetylation!"
I am pretty pumped to try an experiment with Sir2p and NAD right now. Imagine if I had some lying around.
'Is it in a Shark?'
'LOL your Mind has AIDS'
IOYC: So, Counsellor [NAME CENSORED]. How would you compare my Mind to most. Is it in a Problem?
Counsellor [NAME CENSORED]: I tell you what - fuck no. That shit is so dope it hurts my Qualifications.
IOYC: Can you please be fucking serious?
Counsellor [NAME CENSORED]: Let me touch it.
IOYC: Maybe I should Counsel you with this Fist.
Counsellor [NAME CENSORED]: Okay, okay. Let's talk about Mums.
IOYC: Let's talk about me exploding your Childs.
Counsellor [NAME CENSORED]: *cries*
IOYC: LOL you are such a Shit Counsellor.
Counsellor [NAME CENSORED]: I am so rethinking my life choices right now.
IOYC: Dope Transference - I can feel what it is like to suck.
Anyway I totally fucked that shit off and started thinking about other things, like this:
When Shin-ichiro Imai, a postdoc in Guarente's lab, mixed Sir2p, NAD, and part of a histone (a small protein commonly found in association with DNA in chromatin) in a test tube to see if Sir2p added ADP-ribose to the protein tails, he was shaken by the results. The histone molecules did not get heavier, as they would if weighed down by an extra ADP-ribose group. Instead, many of them got lighter by exactly 42 atomic masses. Guarente was reported to shout, "That might be deacetylation!"
I am pretty pumped to try an experiment with Sir2p and NAD right now. Imagine if I had some lying around.
'Is it in a Shark?'